T.O.P.
is a potent synergistic formula that combines safe, powerful Herbs,
Supplements and Extracts for healthy support of your Free Testosterone
level. Since
T.O.P. contains many powerful herbs and extracts, it is suggested
that it be taken continuously for 22 days followed by an eight day break.
Another option is to take the supplements for 5 days per week with a
2 day break and then repeat. Traditionally the body will respond better
to herbs and extracts when
the use is cycled on and off. T.O.P. labels reflect this with
the 22/30 notation signifying 22 days usage out of every month.
Ingredient: Nettle Root Extract
Function: At least six constituents of nettle root inhibit aromatase,
reducing conversion of androgens to estrogens. Nettle extracts also
inhibit enzymes such as 5-alpha-reductase that cause testosterone to
convert to DHT. It also reduces SHBG’s (sex hormone-binding globulin)
binding of free testosterone.
Study Recommended Dosage: 240 mg/day (w/320 mg saw palmetto in
BPH study)
T.O.P. Dosage: 600 mg/day of standardized extract.
Notes: Combining nettle root with Pygeum and Saw Palmetto results
in a stronger, synergistic inhibition. Researchers have identified constituents
of nettle root that bind to SHBG in place of testosterone, thus reducing
SHBG’s binding of free testosterone. Nettle root may influence the blood
level of free (active) steroid hormones by displacing them from the
SHBG binding site. Nettle root also inhibits the binding of SHBG to
the cell membrane of the prostate, eliminating the ability of estrogen
to act on the prostate through SHBG. Research suggests that a constituent
of nettle root inhibits the binding of EGF to human prostate cells.
Nettle also inhibits the binding of Dihydrotestosterone (DHT) to Prostate
cells.
Ingredient: Testofen® (fenugreek extract)
Function: Testofen is a natural solution for promoting Testosterone
levels and healthy libido and immune functions. A clinical study demonstrated
a 98.9% increase of Free Testosterone in men over an 8 week period.
Study Recommended Dosage: 600 mg/day
TOP Dosage: 600 mg/day
Notes: In addition to Testosterone support, Testofen®
also acts like Testosterone by binding to the Testosterone receptor
sites and creating Testosterone like activity. So it's activity is two
fold. Testosterone is not just like turning on a tap wherein you fill
as much of Testosterone as you want. The body has a balancing mechanism
and each human body has it's own threshold for basal Testosterone levels.
Testofen® helps promote healthy Testosterone levels. In addition
it acts like Testosterone and promotes libido and muscle mass. Testofen®
has demonstrated the following in a double blind, randomised, placebo
controlled human clinical study of 60 subjects:
* Promoted healthy free Testosterone levels in the
active group of subjects by 98.9%
* Promoted healthy muscle mass
* Helped regulate BUN [ Blood Urea Nitrogen ] levels in the active group
of participants, signifying regulation in protein catabolism 
Ingredient: Saw Palmetto
Function: Saw palmetto is an effective inhibitor of 5-alpha-reductase
activity which converts Testosterone into DHT (dihydrotestosterone).
DHT enlarges the prostate (BPH) and causes male pattern baldness. Saw
palmetto also reduces SHBG activity.
Study Recommended Dosage: 160-320 mg for men. 200 mg of saw palmetto
and 50 mg of beta-sitosterol twice a day in treating androgenic alopecia
(male pattern baldness).
T.O.P. Dosage: 320 mg/day
Notes: Growing evidence indicates that supplementing with saw
palmetto may also positively modulate the complex system of hormone
metabolism in men and women alike. Saw palmetto’s effects on hormone
metabolism may have important implications for hormone restoration programs
as well as for supporting healthy hair growth and preventing hair loss.
Ingredient: Pygeum
Function: Pygeum inhibits 5-alpha-reductase so that testosterone
cannot be converted to DHT. It strongly decreases hormone binding globulin
(SHBG) and a decrease in DHT binding, indicating that beta-sitosterol
prevents the normal negative action of DHT.
Study Recommended Dosage: 100 – 200 mg daily, 150 mg in the morning
for ED treatment
T.O.P. Dosage: 100 mg/day
Notes: It displays an anti-estrogenic activity in prostatic tissue.
It lowers blood cholesterol (possibly because of an increase in testosterone
levels) and some researchers believe that high cholesterol is an important
factor stimulating prostate growth, possibly because of higher estrogen
levels. It appears to play a role in inhibiting the growth of human
prostate cancer cells by replacing some of the cell membrane's cholesterol,
which changes the membrane lipid composition in such a way that it enhances
an intracellular signaling system which tells cells not to divide.
Ingredient: Lycopene
Function: Lycopene may be an important substance in maintaining
prostate health. A recent clinical trial demonstrated that lycopene
at a dose of 15 mg per day can significantly improve markers of prostate
proliferation. In addition, the strong lipid antioxidant properties
of lycopene make it particularly effective in main-taining healthy LDL
oxidation and protecting against free radical activity on the arterial
wall.
Study Recommended Dosage: 15 mg/day
T.O.P. Dosage: 20 mg/day
Notes: Lycopene, an antioxidant found in tomatoes, is the most
common carotenoid in the plasma and the prostate. Tomato sauce is the
primary source of lycopene in the American diet and is associated with
a 35 percent decreased risk of developing advanced prostate cancer(1).
Higher serum lycopene levels have been associated with up to an 80 percent
reduction in the risk of being diagnosed with prostate cancer. A meta-analysis
measuring the amount of tomatoes in the diet, particularly cooked tomatoes,
showed a 20 percent reduction in prostate cancer risk with increased
consumption(2).
(1)
Giovannucci, E et al: A prospective study of tomato products, lycopene,
and prostate cancer risk. J Natl Cancer Inst Vol. 94:391, 2002
(2) Etminan, M et al: The role of tomato products and lycopene
in the prevention of prostate cancer: A metaanalysis of observational
studies. Cancer Epidemiol Biomarkers Prev Vol. 13:340, 2004.
Ingredient: DIM (diindolylmethane)
Function: Increases the ratio of 2-hydroxyesterone (good estrogen)
to 16-alpha-hydroxyesterone (bad estrogen). It also reduces SHBG activity.
Study Recommended Dosage: 100 mg/day
T.O.P. Dosage: 100mg/day
Notes: From vegetables such as broccoli, brussels sprouts, and
cabbage. DIM helps convert “strong” estrogens into benign or even helpful
estrogens such as 2-hydroxyestrone. Studies have demonstrated that DIM
increases the ratio of 2-hydroxyesterone to 16-alpha-hydroxyesterone,
thereby causing a decrease in “bad” estrogen and an increase in “good”
estrogen. For men, this very well might mean a decrease in prostate
cancer. A 2003 study showed that DIM (an Indole-3-carbinol byproduct)
acts as antiandrogen to halt prostate cancer cell growth. For women,
it also acts very much like tamoxifen (without the side effects) in
blocking undesirable estrogenic effects in breast cancer cells, and
its antiestrogen effects are enhanced with genistein (soy isoflavone).
DIM lowers harmful 4- and 6-hydroxylations. In China, where the risk
of breast and prostate cancers is minuscule, consumption of cruciferous
vegetables (the source of I3C and DIM) is more than three times that
of the US.
Ingredient: Tribulus terrestris
Function: Tribulus has some energy boosting abilities.
Recommended Dosage: 85 to 250 mg up to three times per day
T.O.P. Dosage: 125 mg/day
Notes: Tribulus terrestris extract consisting of saponins appear
to decrease blood sugar increase after a meal. It appears from lab studies
that tribulus terrestris may cause death to certain cancer cells. The
clinical significance of this finding is not clear at this time. Tribulus
terrestris extract does help with healthy erectile function, but it
takes several days for the full benefits. Studies suggest that Tribulus
terrestris provides protection against liver damage.
Ingredient: ZMA
Function: ZMA contains Zinc Monomethionine Aspartate plus Magnesium
Aspartate and vitamin B-6, and is an all-natural product that has been
clinically proven to significantly increase anabolic hormone levels
and muscle strength.
Recommended Dosage: 404 mg/day
T.O.P. Dosage: 404 mg/day
Notes: Lorrie Brilla, PhD, a sports performance researcher at
Western Washington University, recently reported that ZMA significantly
increase free testosterone levels and muscle strength in NCAA football
players. NCAA football players who took ZMA nightly during an eight-week
spring training program had 2.5 times greater muscle strength gains
than a placebo group. The strength of the ZMA group increased by 11.6%
compared to only a 4.6% increasein the placebo group. The ZMA group
had 30% increases in free and total testosterone levels compared to
10 percent decreases in the placebo group. The ZMA group also had a
slight increase in insulin-like growth factor-1 (IGF-1) levels compared
to a 20 percent decrease in the placebo group.
Ingredient: LJ-100® (Eurycoma
longifolia commonly called Tongkat Ali or Longjack at 100:1 Extract)
Function: Human clinical research has confirmed that LJ100®
increases serum testosterone level and DHEA level and decreases SHBG
level considerably.
Recommended Dosage: up to 100mg/day
T.O.P. Dosage: 25 mg/day
Notes: LJ100® Tongkat Ali is the most potent, patented, standardized
extract containing 40% Glyco Saponins, 20-28% bioactive Eurypeptide®
compounds, and 30% Polysacharides. Recent human clinical trials have
shown LJ100 ® to increase IGF1 level and modulate Cortisol level.
Ingredient: Eleuthero (formerly known as
Siberian Ginsing)
Function: Eleuthero is an "adaptogen" (an agent that
helps the body adapt to stress). It is thought to help support adrenal
gland function. Some studies have suggested eleuthero may help boost
energy.
Recommended Dosage: 85 to 250 mg up to three times per day
T.O.P. Dosage: 150 mg/day
Notes: Eleuthero has been used to increase stamina and endurance
in Soviet Olympic athletes. Research has shown that eleuthero improves
the use of oxygen by the exercising muscle. This means that a person
is able to maintain aerobic exercise longer and recover from workouts
more quickly. Preliminary research from Russia indicates it may be effective
for this purpose. Other trials have been inconclusive or have shown
no beneficial effect. Some laboratory studies in cell cultures and animals
have suggested that eleuthero may have immune-boosting properties. Eleuthero
may also support the body by helping the liver detoxify harmful toxins.
Eleuthero has been shown to enhance mental acuity and physical endurance
without the letdown that comes with caffeinated products.
It's
time to feel younger - Call 1-800-809-7241 to order T.O.P. today.
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Information on Male Hormone Balance
Disclaimer:
Regenesis makes no medical claims - Statements
contained herein have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat and cure or prevent
disease. Always consult with your professional health care provider
before changing any medication.
The information is for educational use only. Do not attempt to self-diagnose
or treat any condition. Please consult your healthcare practitioner
if you believe you may have any of the signs or symptoms discussed above
before using any of the nutrients discussed.
You should also consult with a healthcare professional before starting
any diet, exercise or supplementation program, before taking any medication,
or if you have or suspect you might have a health problem. Always
read and follow all label directions.
Caution:
If you are taking any medication, use only under physician
supervision. Men with existing prostate cancer may not be able to use
this product. Elevations in free testosterone can unmask an occult (hidden)
prostate cancer. Anyone with this concern should have a baseline PSA
prior to using this product and a follow-up PSA test 60 days later.
If a significant elevation of PSA is found, discontinue this product
and advise physician.
Warnings:
Keep out of reach of children
Do not exceed recommended dose
Do not use if outer seal is damaged or missing
When using nutritional supplements, please consult with your health
care provider if you are undergoing treatment for a medical condition
or if you are pregnant or lactating.
