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HGH Deficiency Syndrome of Adulthood by Ron Kennedy, M.D. Declining levels of HGH are associated with increased incidence of cardiovascular disease, decreased lean body mass and therefore loss of strength, increased body fat with distribution around the waist area, decreased cardiac output (the amount of blood the heart can pump out per minute), decreased pulmonary capacity (the volume of air you can blow out of your lungs in one breath), decreased bone density, decreased kidney function, increased total cholesterol with decreased HDL, increased triglycerides, loss of interest in sex, impotency, frigidity, depression, loss of concentration, arthritis, increased insulin resistance, adult onset diabetes, decreased heart pumping strength, arthritis, thinning of the skin with wrinkling, thinning and loss of hair, and fatigue with the need for more sleep. HGH has proven to be an excellent therapy for all of these conditions. Most remarkable are preliminary reports that HGH can actually reverse some of the changes in Alzheimer's disease by revitalizing cells which are no longer functioning. Supplementation with HGH reverses every change of aging you can think of. It reduces visceral fat (fat in the abdomen), increases cardiac pumping ability, increases muscular strength, increases pulmonary vital capacity, lowers elevated blood pressure, stops arthritis by allowing the regrowth of degenerated synovial membranes, increases interest and ability in sex, increases mental alertness, lowers cholesterol and triglycerides, raises HDL, remineralizes bone, thickens skin, increases kidney function, helps diabetic patients back to a normal life, lifts depression, and lessens the need for sleep by several hours per night. These many actions reflect the fact that every cell in the body is equipped with HGH receptors. When a doctor familiar with HGH deficiency syndrome does a physical exam, (s)he can see plain evidence of the lack of HGH. The signs which give away this syndrome are some combination of the following: loss of abdominal muscle tone with distension and sometimes "hanging over" of the tummy, sagging breasts in both sexes, hair loss, wrinkles especially with loose skin over the eyes (sagging upper eyelids) and loose skin hanging in a fold in the anterior neck under the chin, varicose veins, and soft muscles; on exam the skin is easily pulled into folds. Try this test: pull a fold of skin from the back of the hand between the thumb and index finger. It should pop back within one second after release. If it does not, you are deficient in HGH. The Biochemistry of HGH The biochemistry of HGH is complex. It seems that we all have plenty of HGH, but as we age it is prevented from being released from the pituitary by deficiency of HGH releasing hormone (HGHRH) which is made in the hypothalamus of the brain and by a substance called HGHP, a peptide of seven small amino acids. One day it may be possible to supplement with one or both of these two substances and cause the release of your own HGH; however as yet these are not commercially available. For people who want to get the full benefit of HGH, it is necessary to raise plasma levels to those enjoyed by the average person in his or her 20s. We need 30-50% of the amount children have and very few adults produce and release this much on his/her own. Some of the effect of HGH are immediate: increased energy, ability to concentrate, interest and ability in sex; others take a few months to a year to show up: increased aerobic capacity and strength, thickening of hair, tightening of wrinkles and loose skin, decrease in visceral fat; and one takes two years: strengthening of osteoporotic bones. I prefer to treat illnesses at the most fundamental level and for many of the ailments of "old age" the most fundamental cause is HGH deficiency. The only treatment which fully reverses HGH deficiency is HGH replacement therapy. The Rudman Study of Human Growth Hormone was the landmark study, published in 1990, and more than any other study propelled HGH to the forefront of anti-aging medicine. The Rudman Study of Human Growth Hormone It is known that many of the changes of aging up to age fifty are largely due to falling levels of HGH. It has been suspected that many of these changes, well into old age, sixty and beyond, also are related to growth hormone deficiency but until 1990 that was only a hunch. In that year, Dr. Daniel Rudman and his associates at the Medical College of Wisconsin, gave us some of the answers in their landmark study published in The New England Journal of Medicine. That study was entitled "Effects of Human Growth Hormone in Men Over Sixty Years Old." This has come to be known as "The Rudman Study." The scientific detachment and dryness of this paper belie the exciting results of the study. Signs of aging melted away in twelve men during a one year course of treatment with biosynthetic HGH. There was a dramatic shift in the composition of body weight in this group of men from fat to lean muscle: an increase of 8.8 % in lean muscle mass and a 14.4% decrease in fat tissue. There was also an 8.8% increase in bone density as well, evidence of the reversal of osteoporosis of aging, all in the absence of exercise and in the absence of any changes of health habits. The participants in the study were asked not to change their lifestyle. Those who smoked were asked to keep smoking. Those who led a sedentary lifestyle were asked not to add any extra activities. Therefore, exercise and dietary changes did not account for these exciting changes. From a cosmetic standpoint the most dramatic result was in the skin where there was a 7.1% increase in thickness. Many of the visible changes of aging happen as a result of the fact that skin becomes thinner with age, allowing wrinkles to form. These men looked dramatically younger, most observers said around twenty years younger. In addition, their sex drives increased proportionate to their apparent rejuvenation much to the delight of their wives. As one man on this therapy told me "Growth hormone is great! Everything is growing!" I remember well the report of the Rudman Study on national television in 1990 on Sixty Minutes. Despite the fact that nothing else was done to help these men rejuvenate, they were powerfully rejuvenated in the absence of specific vitamins without thyroid hormone, DHEA, cortisol, etc. Despite the absence of any other changes in lifestyle, these men shed twenty years of the signs of aging! The study was terminated after one year no one knows if these changes continue and become even more dramatic beyond the one year mark. I suspect they do. These men were carefully monitored to see if there were any adverse effects on the kidneys, heart, liver and blood-forming organs. There were none. These men maintained their health while rejuvenating. Of course, one would predict the absence of toxicity from a natural hormone given in doses already known to be produced in a young person. I was reminded of HGH at a recent medical conference when I met a doctor from Lake Forest, California. This man provides HGH for a group of thirty patients and is himself on HGH. He is 61 years old and looks like a healthy and vital forty-year-old man. His young, beautiful wife was having difficulty keeping up with the pace at which he was taking in the exhibits. When I asked him for his secret he reminded me of HGH. Such personal experiences bring to life dry research reports such as The Rudman Study.
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